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. 2013 Sep 9;8(9):e73766. doi: 10.1371/journal.pone.0073766

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© 2013 Bouta et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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TNF-Tg mice (ages 6–11 months) were phenotyped as collapsed by PD-US as described in Figure 6 and then underwent CE-MRI. The 4 of 12 PLN that phenotyped as collapsed via PD-US and expanding via CE-MRI are shown. Note the large synovial volumes present in the adjacent knee, a hallmark of arthritic flare and PLN collapse.