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. 2013 Sep 9;8(9):e75277. doi: 10.1371/journal.pone.0075277

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© 2013 Malherbe et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

PMC Copyright notice

The three-dimensional model of SF162 gp120 monomer (light grey) shows the location of the four PNGS of interest (red spheres) and the N-glycans (blue spheres) important for 2G12 binding. The model was built by homology modeling using the SWISS- MODEL server (http://swissmodel.expasy.org/) based on the structure of the HIV-1 JRFL gp120 core protein complexed with CD4 and the X5 antibody (PDB code 2B4C) [27]. The figure was generated with PyMOL Molecular Graphics System.