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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2012 Sep 18;2(4):443–459. doi: 10.1002/wdev.88

Figure 1. Distinct origins of excitatory neurons and inhibitory interneurons in the developing mouse neocortex.

Figure 1

Excitatory neurons are generated in the proliferative zone of the dorsal telencephalon and then migrate radially to the cortical plate (red arrows). In contrast, inhibitory interneurons are produced in the proliferative zone of the ventral telencephalon, especially the MGE and AEP/POA, and migrate tangentially to reach the neocortex following two major routes (blue dashed arrows). The colored regions indicate the proliferative zones across the embyronic brain expressing different transcription factors that are essential for proper neurogenesis of distinct neuronal populations. AEP: anterior entopeduncular area; H: hippocampus; LGE: lateral ganglionic eminence; LP: lateral pallium; MGE: medial ganglionic eminence; Ncx: neocortex; POA: preoptic area.