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. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Semin Nephrol. 2013 Jul;33(4):314–326. doi: 10.1016/j.semnephrol.2013.05.004

Figure 2. Pax2 Expression Marks the Developing Kidney.

Figure 2

Embryos that carry the enhanced green fluorescent protein inserted into a single allele of Pax2 are show with expression in all tissues that contribute to the kidneys. At E9.0, the nephric duct is visible within the intermediate mesoderm; note the posterior cellular processes that extend as the duct migrates caudally. By E10.0, the nephric duct and mesonephric tubules are well developed; the metanephric mesenchyme (arrow) is adjacent to the posterior duct. By E10.5, the ureteric bud begins to emerge and migrate into the mesenchyme. By E11.5, the ureteric bud has bifurcated and cap mesenchyme is seen aggregating around the tips of the buds. Pax2 expression persists in all of the ureteric bud epithelial and cap mesenchyme derivatives but is down-regulated in more differentiated nephron epithelial cells.