Fig. 5.
NK cells from IA patients exhibit increased cytolytic activity. (A) Representative dot plots show K562 lysis by PBMCs from the three groups at different E:T ratios (3:1, 10:1, and 30:1). Values in the quadrant represent the percentages of K562 lysis. (B) Pooled data show the percentages of K562 lysis by PBMCs from the three groups at the E:T ratio of 30:1. (C) Pooled data show the percentages of K562 lysis by PBMCs from IA patients with high levels (>100 U/L) or low levels (<100 U/L) of serum ALT. (D) Correlation analysis of the percentages of K562 lysis by PBMCs at the E:T ratio of 30:1 and the serum ALT levels in IA patients (n = 31). (E) Pooled data show the lysis efficiency of hepatocellular carcinoma cell lines (including Huh7.5, HepG2, and HepG2215 cells) by PBMCs from IA patients at the E:T ratio of 30:1. The y axis indicates the ratio of target lysis by NK percentages.