Figure 3. HIF-1 inhibitor prevents the influx of monocytes/macrophages into irradiated U251 intracranial GBM and increases their radiation response.
(A) Quantification of CD11b+monocytes and F4/80+macrophage cell influx into GBM tumors. Error bars indicate SEM. **P < 0.01, ***P < 0.001 versus control. (B) Growth curves of i.c. tumors treated with irradiation, NSC-134754, irradiation+NSC-134754, and control (n = 5 per group). Error bars indicate SD. *P < 0.05. From (13) with permission.