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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Semin Radiat Oncol. 2013 Oct;23(4):281–287. doi: 10.1016/j.semradonc.2013.05.002

Figure 4. Therapeutic effect of blocking the interaction of SDF-1 with CXCR4 after whole brain irradiation.

Figure 4

(A) Growth curves of i.c. U251 early tumor model after fractionated irradiation (5 daily doses of 2 Gy starting on day 11 after transplantation) with or without infusion of AMD3100 for 21 days *P < 0.05. (B) BLI images after fractionated irradiation treated with or without AMD3100. (C and D) Growth curves of i.c. U251 advanced tumor model after a single dose of irradiation (15 Gy on day 22 after transplantation), treated with AMD3100 (21 day infusion; (C), *P < 0.05) or with neutralizing anti-CXCR4 Ab (D), *P < 0.05), starting immediately after irradiation. From (13) with permission.