Table 2.
entry | RCOOR’ 12 |
GC yield of ester (%) |
isolated yield of ester (%) |
reaction condition |
---|---|---|---|---|
1 | 12a | 99 | 95 | catalyst 1 mol%, 80 °C, 5 h |
2 | 12b | 97 | 83 | catalyst 1 mol%, 80 °C, 6 h |
3 | 12c | 70 | 61 | catalyst 1 mol%, 80 °C, 30 h |
4 | 12d | 78 | 76 | catalyst 5 mol%, 25 °C, 24 h |
5 | 12e | 99 | 93 | catalyst 1 mol%, reflux, 16 h |
6 | 12f | 81 | 81 | catalyst 1 mol%, 2 eq. acid, reflux, 30 h |
7 | 12g | 92 | 83 | catalyst 1 mol%, 2 eq. acid, reflux, 48 h |
8 | 12h | 55 | 59 | catalyst 10 mol%, reflux, 96 h |
9 | 12i | 61 | 50 | catalyst 1 mol%, reflux, 48 h |
10 | 12j | 40 | 33 | catalyst 10 mol%, reflux, 144 h |
11 | 12k | 99 | 93 | catalyst 1 mol%, reflux, 96 h |
12 | 12l | 74 | 64 | catalyst 10 mol%, reflux, 40 h |
13 | 12m | 84 | 78 | catalyst 10 mol%, 2 eq. alcohol, reflux, 48 h |
Unless otherwise noted, an acid (2 mmol), an alcohol (2 mmol) in isooctane (4 mL).