Figure 36.

SLC4A8 gene structure and NDCBE transcript variants. Scale diagrams showing the human SLC4A8 gene locus together with the position of neighboring genes (A), the position of promoters (P1 and P2), and the position of exons within SLC4A8 (B). Transcript variants are represented, not to scale, as numbered boxes joined by a horizontal line (C). Each numbered box represents the inclusion of that exon in the mature transcript. “//” denotes that all five transcripts include exons 7–24. Exons that include the initiator ATG codon (“M”) and termination codon (“*”) are marked for each transcript. Sequences that are derived from part of a larger exon sequence are labeled with an “a” (e.g., exon 25a is a subdivision of exon 25). Colored exons, or parts of exons, correspond to the protein regions that each encodes, which are identically colored in FIGURE 37. Uncolored exons, or parts of exons, denote untranslated 5′ and 3′ sequence. Exons that are connected with a dashed line are predicted, but not demonstrated, to be included in the mRNA.