Figure 7.

Analysis of common and unique exon boundaries among human SLC4 and Ciona Slc4-like genes. The gray horizontal protein bar represents a region of a typical Slc4 protein, between putative TMs 7–14. White numbered boxes within the protein bar mark the positions of α-helical TMs, similar to the representations in FIGURE 2B. Aligned below the protein bar are the corresponding regions of mRNAs that encode the TMs 7–14 region for all 10 human SLC4 genes and all 3 Ciona Slc4-like genes. Each mRNA bar is divided into colored boxes that represent the individual exons that comprise each sequence: thus a change in color on the horizontal axis marks the position of an exon boundary. Exons that appear to have been derived by splitting of a larger ancestral exon are colored green in the human lineage and purple in the Ciona lineage. Common exon boundaries that are discussed in the text are labeled A–L. The position of the exon boundaries for each gene are provided by NCBI Evidence Viewer (839). The sequence alignment from which this analysis is derived is presented in Appendix III.