Table 5.
RRM1 expression by stage and age: of the younger patients with T4 disease, high RRM1 expressors had a median OS of 2.2 years compared with 1.0 year in the low-expressor cohort. Of the younger patients with node-positive disease, high expressors had a median OS of 10.3 years compared with 2.3 years in low expressors
| T stage | Age < 70 years
|
Age ≥ 70 years
|
||||||
|---|---|---|---|---|---|---|---|---|
| RRM1 high (n = 17) | Median OS, years | RRM1 low (n = 26) | Median OS, years | RRM1 high (n = 25) | Median OS, years | RRM1 low (n = 16) | Median OS, years | |
| N (%): | ||||||||
| T2 | 7 | 8 | 15 (35) | 6 | 7 | 13 (32) | ||
| T2N0 | 7 | 7 | 14 | 5 | 6 | 11 | ||
| T2N1 | 0 | 1 | 1 | 1 | 1 | 2 | ||
| T3 | 8 | 6 | 14 (33) | 15 | 7 | 22 (54) | ||
| T3N0 | 5 | 1 | 6 | 12 | 3 | 15 | ||
| T3N1 | 3 | 5 | 8 | 3 | 4 | 7 | ||
| T4 | 2 | 2.2 | 12 | 1.0 | 14 (33) | 4 | 2 | 6 (15) |
| T4N0 | 2 | 7 | 9 | 3 | 0 | 3 | ||
| T4N1 | 0 | 5 | 5 | 1 | 2 | 3 | ||
| Total nodal+ | 3 | 10.3 | 11 | 2.3 | 14/43 (33) | 5 | 7 | 12/41 (29) |