. Author manuscript; available in PMC: 2013 Sep 10.

Published in final edited form as: Osteoporos Int. 2011 Sep 21;23(5):1521–1531. doi: 10.1007/s00198-011-1763-2

Table 3.

Genome-wide Linkage Results for Osteocalcin Related Traits

Trait^*	Peak LOD	QTL Location^§				Genes Under Peak

		Chrm	cM (range)	Cytogenetic	Position (Mbp)	N	Candidates
TotalOC	2.606	9	60 (57-62)	p13.1-p13.3	33.9-38.4	69	none
TotalOC	2.829	11	170 (162-172)	q24.2-q24.3	124.4-130.2	76	none
TotalOC	2.308	18	93 (89-96)	q21.32-q22.1	56.3-59.9	25	TNFRSF11A(RANK)
TotalOC	2.244	22	24 (17-31)	q12.1-q13.33	20.5-25.5	111	MAPK1; MIF
CarbOC	2.172	5	85 (81-95)	q13.2-q14.1	70.7-80.5	60	GDF5-UQCC
CarbOC	2.049	18	93 (90-97)	q21.32-q22.1	56.3-59.9	25	TNFRSF11A(RANK)
% UcOC	2.151	12	126 (117-136)	q23.1-q24.21	96.2-113.2	142	IGF1; TRPV4

Only regions with a peak LOD >2.0 are shown.

OC: osteocalcin; %UcOC: percent uncarboxylated osteocalcin; CarbOC: carboxylated osteocalcin

Total OC includes adjustment for age, sex, bmi and menopausal status. Carboxylated OC includes adjustment for age, sex, bmi, menopausal status and TV hours. Percent uncarboxylated OC includes adjustment for age, sex, bmi, menopausal status and smoking.

^§

Location defined by the position of the peak LOD±1.0