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. Author manuscript; available in PMC: 2013 Sep 10.
Published in final edited form as: Trends Genet. 2012 Apr 26;28(8):389–396. doi: 10.1016/j.tig.2012.03.013

Figure 1. Epigenetic regulation induced by NATs.

Figure 1

NATs regulate the epigenetic landscape of genomic loci from which they are transcribed (cis regulation). A specific secondary structure permits the NAT to interact with different chromatin-modifying enzymes (green and red shapes), thereby coordinating their action and directing specific epigenetic modifications of the nearby chromatin (green and red flags). Locus specificity may be achieved through sequence-specific interactions between the NAT and the DNA.