Table 1. NF90-8 cell cycle analysis.

NF90-8 cells were treated as indicated above for 24 or 48 hours. Data represent the mean ± SD of three independent experiments.

DNA analysis of NF90-8 MPNST cells
	G1	G2	S	Apoptosis
0 Hours
Untreated	32.0% ± 3.7	37.4% ± 0.8	30.6% ± 4.3	0.2% ± 0.4
24 Hours
DMSO	40.0% ± 2.1	29.0% ± 2.7	30.8% ± 5.2	1.3% ± 0.3
500 nM lovastatin	40.0% ± 2.3	24.5% ± 2.8	35.3% ± 1.2	2.0% ± 0.4
500 nM 1	41.1% ± 1.8	24.7% ± 2.9	34.2% ± 1.3	1.7% ± 0.3
500 nM 1 + 500 nM lovastatin	50.2% ± 2.0 *	25.9% ± 2.0	23.9% ± 3.0	12.6% ± 1.8 *
500 nM 2	41.5% ± 1.6	26.5% ± 2.2	32.0% ± 3.6	1.5% ± 0.5
500 nM 2 + 500 nM lovastatin	49.6% ± 3.4 *	26.2% ± 1.3	24.2% ± 2.7	5.9% ± 0.9
48 Hours
DMSO	44.4% ± 2.4	23.3% ± 2.3	32.3% ± 1.9	2.7% ± 0.4
500 nM lovastatin	46.7% ± 2.6	26.4% ± 1.4	26.9% ± 1.9	3.6% ± 1.0
500 nM 1	43.0% ± 2.5	24.4% ± 1.6	32.6% ± 2.4	3.0% ± 0.7
500 nM 1 + 500 nM lovastatin	62.7% ± 2.9 *	31.0% ± 2.0	6.3% ± 1.1 *	31.4% ± 6.3 *
500 nM 2	40.2% ± 1.3	26.0% ± 1.6	33.9% ± 0.7	1.8% ± 0.7
500 nM 2 + 500 nM lovastatin	55.0% ± 1.0 *	27.0% ± 5.2	18.0% ± 14.8	30.3% ± 3.4 *

^*Statistical significance was determined between the FTI/lovastatin treated cultures and the DMSO controls. Significance was set at p<0.05.