Table 2. ST88-14 cell cycle analysis.

ST88-14 cells were treated as indicated above for 24 or 48 hours. Data represent the mean ± SD of three independent experiments.

DNA analysis of ST88-14 MPNST cells
	G1	G2	S	Apoptosis
0 Hours
Untreated	37.7% ± 10.3	29.8% ± 9.1	32.6% ± 2.2	0.1% ± 0.6
24 Hours
DMSO	51.7% ± 1.3	19.8% ± 1.2	28.6% ± 1.9	0.1% ± 0.0
500 nM lovastatin	50.9% ± 2.0	20.5% ± 1.8	30.5% ± 1.8	0.2% ± 0.1
500 nM 1	51.7% ± 3.3	20.0% ± 1.2	28.4% ± 3.0	0.2% ± 0.1
500 nM 1 + 500 nM lovastatin	58.7% ± 1.6 *	19.0% ± 1.5	22.4% ± 3.1 *	0.2% ± 0.1
500 nM 2	49.5% ± 1.8	20.0% ± 0.7	30.6% ± 1.3	0.1% ± 0.1
500 nM 2 + 500 nM lovastatin	60.0% ± 0.9 *	19.2% ± 2.4	22.8% ± 2.6 *	0.2% ± 0.0
48 Hours
DMSO	60.9% ± 5.8	13.1% ± 1.8	26.0% ± 4.4	0.4% ± 0.2
500 nM lovastatin	56.7% ± 5.6	13.8% ± 1.6	29.5% ± 4.3	0.6% ± 0.4
500 nM 1	59.2% ± 3.2	15.2% ± 2.1	25.6% ± 3.0	0.5% ± 0.5
500 nM 1 + 500 nM lovastatin	77.2% ± 3.0	13.1% ± 2.1	9.7% ± 3.0 *	8.9% ± 5.2 *
500 nM 2	57.0% ± 2.7	14.3% ± 1.2	28.8% ± 2.0	0.7% ± 0.5
500 nM 2 + 500 nM lovastatin	74.7% ± 1.6	11.5% ± 0.5	13.9% ± 1.3 *	5.7% ± 1.7 *

^*Statistical significance was determined between the FTI/lovastatin treated cultures and the DMSO controls. Significance was set at p<0.05.