Table 2. CK-18 M30, MMP-2, ALT, AST, HBV DNA, AFP, PLT, and Albumin Levels Versus Fibrosis Stages at Liver Biopsy .
| Stage 1, (n = 40) | Stage 2, (n = 77) | Stage 3, (n = 37) | Stage 4, (n = 230 | Stage 5, (n = 12) | P value | |
|---|---|---|---|---|---|---|
| CK-18 M30 (U/L) | 168 (1-292) | 259 (102-761) | 396 (259-598) | 462 (400-598) | 689 (559-762) | 0.001 |
| MMP-2 (ng/ml) | 2.7 (1.1-6.1) | 2.8 (2.0-6.1) | 3.4 (2.2-6.1) | 4.6 (2.6-6.1) | 5.7 (2.4-6.8) | 0.001 |
| ALT a | 77.5 (16-476) | 90 (14-665) | 124.5 (25-476) | 120 (37-346) | 122 (25-219) | 0.001 |
| AST a | 50.5 (15-230) | 77 (20-552) | 102 (35-322) | 96 (35-350) | 112 (21-205) | 0.001 |
| HBV a DNA | 4.5x107(6x104-7.7x109) | 9.3x107 (2.4x105-3.4x1010) | 1.1x109 (1.1x105-3.3x109) | 3.8x107 (3.9x106-9x109) | 2.8x107 (1x106-7.2x108) | 0.001 |
| AFP a | 2.8 (1-14) | 3.1 (1-12) | 3.3(1-9) | 2.9 (1-5) | 3.1(1-4) | 0.110 |
| Platelet | 2.7x105 (1.1x105-4.1x105) | 2.5x105 (1.4x105- 4.2x105) | 2x105 (8.9x104-4.5x105) | 1.8x105 (7x104-3.5x105) | 1.9x105 (8.8x104-4x105) | 0.001 |
| Albumin | 3.8 (3.2-5.0) | 3.9 (3.3-5.0) | 3.8 (3.4-4.9) | 3.9 (3.0-4.3) | 3.7 (3.0-4.6) | 0.483 |
aAbbreviations: AFP, alpha-fetoprotein; ALT, serum alanine aminotransferase; AST, aspartate aminotransferase; HBV, hepatitis B virus