Skip to main content
. Author manuscript; available in PMC: 2014 Aug 2.
Published in final edited form as: Org Lett. 2013 Jul 23;15(15):3950–3953. doi: 10.1021/ol401727y

Table 1.

Survey of solvents in the Suzuki–Miyaura coupling.agraphic file with name nihms-508899-t0002.jpg

entry solvent, temp yieldb entry solvent, temp yieldb
1 toluene, 110 °C 100% 6 t-amyl alcohol, 100 °C 100%
2 acetone, 75 °C 96% 7 MTBE, 80 °C 100%
3 EtOAc, 100 °C 100% 8 2-Me-THF, 80 °C 100%
4 i-PrOAc, 110 °C 100% 9 DMSO, 110 °C 0%
5 n-BuOH, 110 °C 0% 10 acetonitrile, 100 °C 99%
a

Conditions: NiCl2(PCy3)2 complex (5 mol %), sulfamate substrate 1 (1.00 equiv), 2 (2.50 equiv), K3PO4 (4.50 equiv), hexamethylbenzene (0.10 equiv), 12 h.

b

Yield of 3 determined by 1H NMR analysis of crude reaction mixtures using hexamethylbenzene as an internal standard.