Table 2.

Left Ventricular Physiological Studies

	6 Weeks			4 Months			7 Months
	Control (n=8)	AAV8.UCn2 (n=7)	p Value	Control (n=8)	AAV8.UCn2 (n=7)	p Value	Control (n=5)	AAV8.UCn2 (n=6)	p Value
LVP (mmHg)	87±4	95±5	0.36	94±4	96±5	0.76	88±3	91±4	0.58
LV +dP/dt (mmHg/sec)	6899±658	10860±810	0.002	6380±430	10980±1067	0.001	5676±347	10330±578	0.0001
LV −dP/dt (mmHg/sec)	−6532±580	−7245±756	0.46	−6516±312	−8883±741	0.009	−6030±502	−8010±451	<0.02
CO (ml/min)	13±4	18±3	0.35	ND	ND	ND	7±1	13±1	0.015
MAP (mmHg)	70±3	73±6	0.43	ND	ND	ND	67±3	65±1	0.69
MAP/CO mmHg/ml	13±4	6±3	0.35	ND	ND	ND	12±2	10±5	0.74
HR (beats/min)	453±18	511±21	0.05	461±21	520±27	0.10	432±23	539±13	0.003

CO, cardiac output; Con, control; LVP, left ventricular developed pressure; HR, heart rate; MAP, mean arterial pressure; ND, no data.

Note: Values represent means±SE. Values of p were determined by Student t test between groups (unpaired, two-tailed).