Table 3.
Necropsy
| |
6 Weeks |
4 Months |
7 Months |
||||||
|---|---|---|---|---|---|---|---|---|---|
| Control (n=4) | AAV8.UCn2 (n=6) | p Value | Control (n=8) | AAV8.UCn2 (n=8) | p Value | Control (n=6) | AAV8.UCn2 (n=6) | p Value | |
| BW, g | 28±1 | 29±1 | 0.16 | 30±1 | 32±1 | 0.01 | 31±1 | 32±1 | 0.30 |
| LV, mg | 93±5 | 87±3 | 0.31 | 104±5 | 89±2 | 0.03 | 103±3 | 92±3 | 0.01 |
| LV/BW, mg/g | 3.3±0.2 | 3.0±0.1 | 0.09 | 3.5±0.2 | 2.8±0.1 | 0.002 | 3.3±0.1 | 2.9±0.1 | 0.006 |
| Liver, g | 1.5±0.4 | 1.4±0.6 | 0.16 | 1.4±0.6 | 1.4±0.3 | 0.27 | 1.5±0.7 | 1.4±0.2 | 0.18 |
| Lung, mg | 150±7 | 170±6 | 0.07 | 161±4 | 159±7 | 0.74 | 170±6 | 173±5 | 0.64 |
BW, body weight; LV, left ventricle.
Note: Values of p were determined by Student t test (unpaired, two tailed).