Table 2.
Antibiotic | Break Point* µg/ml | MIC in µg/ml | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | 64 | 128 | 256 | 512 | ||
β-lactams: | |||||||||||||
a. Penicillins: | |||||||||||||
Ampicillin | 0.25 | 17 | 15 | 13 | 9 | 14 | 12 | 14 | 9 | 13 | 8 | 6 | 2 |
Amoxycillin | 0.25 | 24 | 16 | 6 | 7 | 15 | 18 | 10 | 13 | 9 | 7 | 6 | 1 |
Oxacillin | 2 | 18 | 35 | 32 | 15 | 7 | 8 | 5 | 6 | 2 | 2 | 1 | 1 |
b.Cephalosporins: | |||||||||||||
Cephalexin | 16 | 2 | 3 | 5 | 7 | 5 | 8 | 16 | 28 | 19 | 23 | 12 | 4 |
Cefuroxime | 8 | 3 | 5 | 6 | 8 | 13 | 11 | 17 | 24 | 20 | 14 | 8 | 3 |
Cefoperazone | 16 | 5 | 5 | 6 | 3 | 21 | 1 | 12 | 14 | 23 | 14 | 7 | 0 |
Cefotaxime | 8 | 2 | 2 | 6 | 12 | 24 | 22 | 14 | 6 | 28 | 17 | 12 | 1 |
Cefepime | 8 | 17 | 28 | 13 | 12 | 3 | 8 | 12 | 23 | 11 | 0 | 0 | 0 |
β-lactam β-lactamase | |||||||||||||
inhibitor combinations: | |||||||||||||
Amp/Sul** | 8 | 8 | 22 | 17 | 10 | 16 | 14 | 6 | 21 | 10 | 8 | 0 | 0 |
Amox/Clav** | 4 | 10 | 15 | 17 | 21 | 26 | 19 | 12 | 8 | 4 | 0 | 0 | 0 |
Aminoglycosides: | |||||||||||||
Gentamicin | 4 | 11 | 18 | 28 | 32 | 20 | 8 | 7 | 5 | 3 | 0 | 0 | 0 |
Amikacin | 16 | 24 | 30 | 43 | 24 | 5 | 3 | 3 | 0 | 0 | 0 | 0 | 0 |
Fluoroquinolones: | |||||||||||||
Ciprofloxacin | 1 | 22 | 18 | 35 | 23 | 14 | 7 | 6 | 4 | 3 | 0 | 0 | 0 |
Norfloxacin | 4 | 10 | 3 | 22 | 6 | 26 | 27 | 16 | 10 | 9 | 3 | 0 | 0 |
Ofloxacin | 1 | 24 | 21 | 32 | 23 | 16 | 9 | 5 | 1 | 1 | 0 | 0 | 0 |
Levofloxacin | 1 | 33 | 42 | 20 | 26 | 5 | 3 | 3 | 0 | 0 | 0 | 0 | 0 |
Gatifloxacin | 0.5 | 68 | 30 | 29 | 1 | 2 | 2 | 0 | 0 | 0 | 0 | 0 | 0 |
Macrolides: Erythromycin | 0.5 | 20 | 9 | 12 | 14 | 16 | 25 | 14 | 8 | 6 | 5 | 2 | 1 |
Lincosamides: Clindamycin | 0.5 | 36 | 30 | 21 | 9 | 6 | 10 | 8 | 5 | 4 | 2 | 1 | 0 |
Tetracyclines: Tetracycline | 4 | 2 | 15 | 10 | 12 | 5 | 20 | 18 | 15 | 10 | 5 | 7 | 3 |
Glycopeptides: Vancomycin | 4 | 21 | 20 | 29 | 25 | 17 | 8 | 10 | 2 | 0 | 0 | 0 | 0 |
Phenicols: Chloramphenicol | 8 | 6 | 8 | 10 | 19 | 6 | 25 | 12 | 16 | 10 | 8 | 7 | 5 |
Ansamycins: Rifampicin | 1 | 14 | 25 | 31 | 26 | 20 | 9 | 5 | 2 | 0 | 0 | 0 | 0 |
Break points of different antibiotics according to CLSI (2005).