Table 1.
Variations in minimal inhibitory concentration (MIC), MIC50, and MIC90 for isolates of C. albicans, C. parapsilosis, C. tropicalis, C. glabrata, and C. krusei in nonpregnant patients, for four antifungal drugs, determined by CLSI testing.
| Samples and Antifungal Drugs | CLSI | ||
|---|---|---|---|
| Range (µg/mL) | MIC50 (µg/mL) | MIC90 (µg/mL) | |
| C. albicans (51) | |||
| Ketoconazole | 0.015 – 0.25 | 0.015 | 0.015 |
| Fluconazole | 0.12 – 1.0 | 0.25 | 0.50 |
| Itraconazole | 0.015 – 0.12 | 0.03 | 0.06 |
| Amphotericin B | 0.015 – 0.5 | 0.06 | 0.12 |
| C. parapsilosis (10) | |||
| Ketoconazole | 0.015 – 0.03 | 0.015 | 0.03 |
| Fluconazole | 0.12 – 2.0 | 0.25 | 1.0 |
| Itraconazole | 0.015 – 0.06 | 0.015 | 0.03 |
| Amphotericin B | 0.015 – 0.12 | 0.03 | 0.12 |
| C. tropicalis (4) | |||
| Ketoconazole | 0.015 – 0.015 | 0.015 | - |
| Fluconazole | 0.12 – 0.5 | 0.12 | - |
| Itraconazole | 0.015 – 0.06 | 0.015 | - |
| Amphotericin B | 0.12 – 0.12 | 0.12 | - |
| C. glabrata (3) | |||
| Ketoconazole | 0.015 – 0.25 | 0.06 | - |
| Fluconazole | 0.12 – 4.0 | 0.12 | - |
| Itraconazole | 0.015 – 0.25 | 0.06 | - |
| Amphotericin B | 0.015 – 0.25 | 0.03 | - |
| C. krusei (2) | |||
| Ketoconazole | 0.06 – 1.0 | - | - |
| Fluconazole | 2.0 – 64 | - | - |
| Itraconazole | 0.25 – 0.25 | - | - |
| Amphotericin B | 0.015 – 0.5 | - | - |