| University of Miami |
Behavioral management and stress responses in
HIV/AIDS |
Interventional |
Randomized design, about 50 %
(n = 227) cognitive-behavioral stress
management (CBSM) group-based psychosocial intervention, 50 %
(n = 170) regular control. Participants
received medication adherence training by a clinical pharmacist |
Psychosocial intervention |
10 weeks |
1997–2003 |
404 |
18 months |
| University of Pittsburgh |
Improving adherence to antiretroviral
therapy |
Interventional |
Subjects are randomized to one of three groups
of structured and individualized interventions and usual care (control)
with the 100 % adherers being followed separately. Both
interventions are being delivered by telephone. Subjects in the
intervention groups are further randomized to booster/no booster
following the maintenance program. Intervention was based on social
cognitive theory and self efficacy theory |
Telephone interventions: structured or
individualiz-ed. Tapered maintenance program. |
28 weeks |
2003–2009 |
349 |
19 months |
| University of Washington |
Peer and pager support to enhance
antiretroviral adherence (PAL) |
Interventional |
About 180 subjects are in the intervention.
The pager arm has 60, the “buddy” arm has 60, and
another 60 received both “buddy” and pager. The
intervention is based on social support theory |
Pager; “buddy”; both
“buddy” and pager |
12 weeks |
2002–2009 |
224 |
9 months |
| University of Pittsburgh |
Adherence to protease inhibitors |
Interventional |
Subjects were randomized to treatment
(n = 99) or usual care/control
(n = 101). 15 perfect adherers (100
% adherence) were followed separately. A 12 week structured
telephone intervention was provided, followed by a 16 week tapered
maintenance program. Intervention was based on social cognitive theory
and self efficacy theory |
Structured telephone intervention; tapered
maintenance program |
28 weeks |
1998–2003 |
215 |
13 months |
| Columbia University & NYSPI |
Serodiscordant couples, medical adherence and
HIV risk (SMART) |
Interventional |
106 were randomized to the intervention arm.
The intervention consisted of four 45–60 min sessions delivered
over 5 weeks (between the Baseline and Week 8 assessment) by a Nurse
Practitioner in a clinic setting. Intervention was grounded in
Ewart' s Social Action Theory and aimed to improve
adherence. |
Counseling |
5 weeks |
2000–2004 |
215 |
8 months |
|
Couples study |
|
Skills, motivation, & support for
adherence from relationship partner |
|
|
|
|
|
| University of Missouri-Kansas City |
ART adherence: enhanced counseling and
observed therapy |
Interventional |
Three arms (n = 202
total). 2 of 3 groups (137 subjects) receive adherence intervention
[Motivational interviewing (MI) counseling alone (69 subjects),
or MI plus modified observed therapy with one dose observed every day
(68 subjects)] and the third group (65 subjects) was standard
care. The intervention was based on information-motivation-behavioral
skills, Motivational Interviewing and self-determination theory |
MI counseling alone; MI plus modified observed
therapy |
24 weeks |
2004–2008 |
202 |
12 months |
| RAND |
California cooperative treatment group (CCTG)
578 |
Interventional |
The intervention consisted of adherence
counseling using cognitive-behavioral components administered by
research nurses over 5 week sessions (3 prior to starting ART, and two
during first 2 weeks of ART); there were 2 intervention arms in the
study—one received the cognitive behavioral intervention (66
subjects, and the other received the cognitive behavioral intervention
plus a 2-week pre-ART practice trial with placebo pills (66 subjects).
And a non-intervention control (67 subjects) uses social cognitive
theory |
Cognitive behavioral intervention or
cognitive-behavioral intervention plus 2-week pre-ART practice
trial; |
5 weeks |
2000–2002 |
199 |
12 months |
| Tufts University |
Understanding and improving adherence in HIV
disease |
Interventional |
The primary intervention (n
= 111) consists of an ARV adherence report shared with
physicians. This report summarizes the subject's adherence
between visits using both self-reported items and electronic MEMS
data |
Randomized, report sharing, cross-over,
intervention study |
20 weeks |
2001–2003 |
156 |
24 months |
| University of North Carolina (UNC) at Chapel
Hill |
Participating and communicating together
(PACT) |
Interventional |
2-arm block, randomized, controlled design to
compare adherence (at 12-week follow-up) of subjects receiving a
Motivational Interviewing (MI) intervention with those receiving a
dose-matched HIV informational control program. Intervention consisted
of 3 components: (1) a 20-minute audiotape and booklet immediately
before seeing their medical provider, (2) 2 one-on-one sessions with a
health educator at weeks 4 and 8 of follow-up, and (3) a mailing 2 weeks
after each individual session. Control group materials were comparable
to the intervention in length and format to control for the placebo
effect of exposure but provided general HIV information only |
MI counseling |
12 weeks |
1999–2004 |
155 |
3 months |
| University of California, Los Angeles
(UCLA) |
Adherence and efficacy of protease inhibitor
therapy (ADEPT) |
Observational |
N/A |
N/A |
N/A |
1997–2000 |
145 |
12 months |
| Ohio State University |
AIDS clinical trail group (ACTG) 731 |
Interventional |
2-arm study. Subjects were randomly assigned
to receive either standard ACTG clinic-based subject education (SC
= 55) or, in addition to standard care, a more intensive
approach (TX = 53) that included telephone calls delivered at
regular intervals by a trained, registered nurse over the first 16 weeks
of antiretroviral therapy. Structured phone calls, conducted from a
central site, were tailored to the individual and were designed to
address common barriers to adherence and promote self-care strategies.
The intervention was guided by self-regulation theory |
Structured telephone support |
16 weeks |
1998–2003 |
109 |
16 months |
| University of California, San Francisco
(UCSF) |
Research in access to care in the homeless
(REACH) |
Observational |
N/A |
N/A |
N/A |
1997–2002 |
108 |
60 months |
| Albert Einstein College |
HIV epidemiology research on outcomes (HERO
adherence study) |
Observational |
N/A |
N/A |
N/A |
1998–2004 |
104 |
6 months |
| University of North Carolina (UNC) at Chapel
Hill |
Directly observed therapy (DOT) |
Interventional |
Directly observed therapy (DOT) (25 subjects)
and regular kept on person (KOP) control (75 subjects) |
Directly observed therapy |
48 weeks |
2000–2005 |
102 |
12 months |
| Yale University |
Rewards improve medication compliance for HIV
treatment (REWARDS) |
Interventional |
Randomized controlled trial comparing
supportive counseling to counseling involving review of MEMS data and
prizes for MEMS-verified medication-taking. Participants used MEMS caps
for 4 weeks. Those with adherence to dose-time less than 80 %
were randomly assigned to 16 weeks counseling and 16 weeks follow-up.
(16 weeks of weekly meetings.) Based on contingency management
theory |
Supportive counseling vs. counseling with MEMS
review and reinforcement. |
16 weeks |
2002–2005 |
97 |
9 months |
| University of Pennsylvania |
Adherence to protease inhibitors in HIV |
Observational |
N/A |
N/A |
N/A |
2005–2006 |
76 |
4 months |
