Table 1.
High LDL-C | Control | |
---|---|---|
History of coronary heart disease at very high risk* | LDL-C ≥ 70 mg/dL or use of lipid-lowering therapy | LDL-C < 70 mg/dL |
History of coronary heart disease† or risk equivalent | LDL-C ≥ 100 mg/dL or use of lipid-lowering therapy | LDL-C < 100 mg/dL |
2+ coronary heart disease risk factors and 10 year Framingham risk of 10 – 20% | LDL-C ≥ 100 mg/dL or use of lipid-lowering therapy | LDL-C < 100 mg/dL |
10 year Framingham risk < 10% | LDL-C ≥ 130 mg/dL or use of lipid-lowering therapy | LDL-C < 130 mg/dL |
0–1 coronary heart disease risk factors | LDL-C ≥ 160 mg/dL or use of lipid-lowering therapy | LDL-C < 160 mg/dL |
LDL-C: low-density lipoprotein cholesterol; CHD: coronary heart disease
Very high risk defined by having a history of CHD and diabetes mellitus, cigarette smoking and/or the metabolic syndrome
Not including individuals at very high risk
Coronary heart disease risk equivalents included diabetes mellitus and stroke
Coronary heart disease risk factors include older age (≥55 years for women and ≥45 years for men), current cigarette smoking, hypertension, family history of coronary heart disease (history of myocardial infarction or angina before age 50 years among first-degree relatives), and low HDL-cholesterol. HDL cholesterol ≥ 60 mg/dL is considered protective and offsets the presence of one these risk factors.