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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Nat Neurosci. 2013 Jul 7;16(8):1060–1067. doi: 10.1038/nn.3454

Figure 8. Altering competitive balance among VPN TCAs rescues representations deleted from S1 body map in cKO.

Figure 8

(a) 5HT staining on tangential sections of flattened cortex at PND7 shows that only 4 barrel rows were evident in PMBSF in S1 in cKO mice, with row ‘A’ being absent. (b) Lesion of the ‘C’ row of large facial whisker follicles in cKO mice within a few hours of birth diminishes ‘C’ barrel row in S1 (blue arrowhead in b) and partially rescues VPN TCA input to row ‘A’ in S1 PMBSF (black arrows b), resulting in five rows in PMBSF as in wildtype compared to four PMBSF rows in un-lesioned cKO mice. (c)Increasing S1 size in Pax6 cKO mice by cortex-specific expression of a Pax6 transgene (cKO; cTG) also partially rescues the ‘A’ row in PMBSF of S1. Abbreviations: A: anterior, TCA: thalamocortical axons. Scale bar in a: 250μm.