Structure of the bacterial transcription initiation complex. The cartoon representation was derived from an EM structure of the initiation complex (PDB: 3iyd) in association with DNA that contains the α, β, β′, ω, σ70 and the wHTH domains of CRP (CAP) transcription factor. For increased clarity, only the key globular domains of these proteins are shown and labeled. The remaining parts of the structure are shown as coils.