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. 2013 Sep 10;11(9):e1001651. doi: 10.1371/journal.pbio.1001651

Figure 8. Super-coarse-grained models of CRP/FNR family transcription factors.

Figure 8

(A) The elastic block representation that emerges from constraining all residues whose relative spatial fluctuations are less than 3 Å to a single rigid domain. This procedure creates two blocks in each monomer. (B) The corresponding ENM model in which each block is accorded a single internal mode. The plots of cooperativity as a function of the reduced two-dimensional design space of the effective internal and coupling elastic strengths of the super-coarse-grained model are shown for CAP (C) and GlxR (D). All other parameters for the models identified in (B) are set to wild-type values deduced from the full ENMs.