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| GlxR Protein | K 2/K 1 (ENM) | Mean K 2/K 1 (ITC) | S.E.M. (n) | p Value |
| Wild-type | 2.37 | 19.47 | 1.12 (18) | - |
| L134V k L134/k = 0.25 | 2.07 | 4.34 | 0.21 (26) | <0.001 |
| A131V k A131/k = 4 | 2.05 | 4.36 | 0.21 (30) | <0.001 |
The ratio of the second to first dissociation constants for cAMP (K 2/K 1) for wild-type and mutant GlxR proteins were calculated from the ENM or obtained by ITC. The p value is for a comparison of means to the wild-type.
