Table 1. Categorization of CLN5 N-glycosylation sites.
N-glycosylation Residue(s) | Function | Localization(if lacking) |
N179, N252, N304, N320, N330* | Folding | ER |
N401 | Trafficking | Golgi** |
N192, N227 | Lysosomal function | Lysosome |
some N330Q protein can be observed in the lysosome.
N401Q mutant is temporarily accumulated in the Golgi and then secreted to the media.