Fig. 5.

Validation of labeled proteins by SRM analysis. Graphical representation of the abundance (upper panels) and representative extracted ion chromatograms (lower panels) of the transitions observed for angiotensinogen, EGF containing fibulin, gelsolin, and prostaglandin D2 synthase. Significant increases (p < 0.05) in the expression of angiotensinogen, EGF containing fibulin and gelsolin were observed in patients with respect to healthy subjects, whereas prostaglandin D2 synthase expression decreased significantly (p < 0.01) in AS patients with respect to healthy subjects. *In chromatograms: Isobaric or nearly isobaric peptides.