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Model of metabolic flux regulation of sialylation in pancreatic β-cell insulinoma. (1) Slow CMP-NeuAc synthesis is caused by slow glycolysis and/or slow epimerization (hatched line) of UDP-GlcNAc by feedback inhibition of the activity of UDP-GlcNAc 2-epimerase by CMP-NeuAc. (2) low sialylation and (3) low amounts of sialo glycans and abundant asialo N-glycans (hatched line). No significant differences in hyaluronan synthesis and O-GlcNAcylation (solid line).
