Figure 1. Mean arterial blood pressure and methylglyoxal (MG) levels in the aorta and kidney of high fructose diet treated Sprague-Dawley rats.

Groups (n = 8 each) of 5 week old male Sprague-Dawley rats were treated for 16 weeks with a high fructose diet (Fruc, 60% of total calories). Control rats received normal chow. Metformin (Met, 500 mg/kg/day in drinking water) was used as a MG scavenger. Mean arterial pressure was measured with an intra-carotid artery catheter in anesthetized rats. MG levels were determined with HPLC. **P<0.01 vs. respective control (Con). ^† P<0.05, ^†† P<0.01 vs. respective Fruc group.