Figure 4. Phosphorylated extracellular signal-related kinases 1/2 (p-Erk 1/2), Erk 1/2 and NFATc expression in the aorta and kidney of high fructose diet treated Sprague-Dawley rats.

Groups (n = 8 each) of 5 week old male Sprague-Dawley rats were treated for 16 weeks with a high fructose diet (Fruc, 60% of total calories). Control rats received normal chow. Metformin (Met, 500 mg/kg/day in drinking water) was used as a MG scavenger. Protein expression was determined by Western blotting using appropriate primary antibodies.