Table 2. Logistic regression analysis of associations between the genotypes of CASP7 and gastric cancer risk.
| Variants | Genotypes | Cases (N = 1,117) | Controls (N = 1,146) | P a | Crude OR (95% CI) | P | Adjusted OR (95% CI) | P b | |
| rs10787498 | |||||||||
| TT | 727 (65.1) | 734 (64.1) | 0.286c | 1.00 | 1.00 | ||||
| GT | 347 (31.1) | 352 (30.7) | 1.00 (0.83–1.19) | 0.959 | 1.00 (0.83–1.19) | 0.960 | |||
| GG | 43 (3.9) | 60 (5.2) | 0.72 (0.48–1.09) | 0.117 | 0.74 (0.50–1.12) | 0.154 | |||
| TT/GT | 1074 (96.2) | 1086 (94.8) | 1.00 | 1.00 | |||||
| GG | 43 (3.9) | 60 (5.2) | 0.114d | 0.73 (0.49–1.08) | 0.115 | 0.75 (0.50–1.12) | 0.152 | ||
| rs1127687 | |||||||||
| GG | 684 (61.2) | 702 (61.3) | 0.769c | 1.00 | 1.00 | ||||
| AG | 376 (33.7) | 378 (33.0) | 1.02 (0.86–1.22) | 0.819 | 1.02 (0.85–1.21) | 0.862 | |||
| AA | 57 (5.1) | 66 (5.8) | 0.89 (0.61–1.28) | 0.523 | 0.90 (0.62–1.30) | 0.575 | |||
| GG/AG | 1060 (94.9) | 1080 (94.2) | 1.00 | 1.00 | |||||
| AA | 57 (5.1) | 66 (5.8) | 0.491d | 0.88 (0.61–1.27) | 0.492 | 0.89 (0.62–1.29) | 0.550 | ||
| rs12247479 | |||||||||
| GG | 885 (79.2) | 889 (77.6) | 0.615c | 1.00 | 1.00 | ||||
| AG | 210 (18.8) | 231 (20.2) | 0.91 (0.74–1.13) | 0.394 | 0.91 (0.74–1.12) | 0.380 | |||
| AA | 22 (2.0) | 26 (2.3) | 0.85 (0.48–1.51) | 0.581 | 0.86 (0.48–1.53) | 0.601 | |||
| GG/AG | 1095 (98.0) | 1120 (97.7) | 1.00 | 1.00 | |||||
| AA | 22 (2.0) | 26 (2.3) | 0.621d | 0.87 (0.49–1.54) | 0.623 | 0.87 (0.49–1.55) | 0.645 | ||
| rs4353229 | |||||||||
| CC | 197 (17.6) | 189 (16.5) | 0.074c | 1.00 | 1.00 | ||||
| CT | 535 (47.9) | 509 (44.4) | 1.01 (0.80–1.27) | 0.944 | 1.00 (0.79–1.27) | 0.978 | |||
| TT | 385 (34.5) | 448 (39.1) | 0.83 (0.65–1.05) | 0.118 | 0.83 (0.65–1.06) | 0.135 | |||
| CC/CT | 732 (65.5) | 698 (60.9) | 1.00 | 1.00 | |||||
| TT | 385 (34.5) | 448 (39.1) | 0.023 d | 0.82 (0.69–0.97) | 0.023 | 0.83 (0.70–0.98) | 0.032 | ||
| Combined effect of risk genotypes | |||||||||
| 0 | 732 (65.5) | 692 (60.4) | 0.011 | 1.00 | 1.00 | ||||
| ≥1 | 385 (34.5) | 454 (39.6) | 0.81 (0.68–0.95) | 0.011 | 0.81 (0.68–0.96) | 0.018 | |||
CI, confidence interval; OR, odds ratio.
a
Chi square test for genotype distributions between cases and controls.
b
Adjusted for age, sex, smoking and drinking status in logistic regress models.
c
For additive genetic models;
d
for recessive genetic models. The results were in bold, if the 95% CI excluded 1 or P<0.05.