Figure 4. Knockout of CD146 in the nervous system resulted in decreased locomotor activity in mice.

(A) Mice at the ages of 1 month and 3 months were subjected to the Rotarod test. Falling latency was recorded with a 30 seconds cut-off time. Mice at the ages of 1 month, 3 months and 6 months were subjected to the open field test. Representative running tracks of mice at the age of 3 months were shown (B). B: begin-point. E: end-point. During the 5-min free running, distance travelled (C), maximum speed (D) and rest time (E) of WT and CD146^ns-ko mice were recorded and analyzed with a two-way ANOVA. Data is presented as means ± SEM.