Table 7. Data of IMRT for locally recurrent NPC.
Lu et al [6] | Chua et al [8] | Lee et al [10] | Han et al [7] | Qiu et al [9] | Current study | |||
---|---|---|---|---|---|---|---|---|
CMT | EBRT | |||||||
Case | 49 | 31 | 13 | 16 | 239 | 70 | 54 | |
rT stage | ||||||||
rT1 | 8.1% | 10% | 69% | 25% | 6.7% | 4.3% | 5.6% | |
rT2 | 18.4% | 16% | 15% | 6% | 18% | 35.7% | 14.8% | |
rT3 | 22.4% | 29% | 15% | 31% | 29.7% | 28.6% | 16.7% | |
rT4 | 51% | 45% | 0 | 38% | 45.6% | 34.3% | 63% | |
GTV | 47.2ml | 28.1ml | NR | 37.69ml | NR | 59.4ml | ||
PTV | NR | 39.2ml | NR | NR | NR | 134ml | ||
Dose | 71.4Gy (68.7-75.4) | 56.8 (50.2-64), 32.3% had SRS boost of 8.5-12.5Gy | 45Gy of EBRT and 20Gy of brachy- therapy | 59.4Gy (39.6-61) | 69.94Gy (61.7-78.7) | 70Gy (50-77.4) | 68.5Gy (49.8-76.8) | |
Chem | NR | 68% of induction | 93% of peri-radiation 79.3% of concurrent | 49% | 70% of concurrent | 51.9% | ||
LC | 100%-9m | 61% -1 y | 53%- 5y | 52%- 5y | 85.8% -5y | 49.3% -3y | 66.1%-2y | |
OS | NR | 63% -1 y | 60%- 5y | 57% -5y | 44.9% -5y | 51.9% -3y | 44.3% -2y | |
Late toxicity | 25% | 8% | 75% | 70.3% | 35.7% | 48.1% | ||
Brain necrosis | NR | 7% | 8% | 18.8% | 25.8% | NR | 18.5% | |
Soft tissue necrosis | NR | 0 | 0 | 0 | 40.6% | 15.7% | 31.5% | |
Cranial neuropathy | NR | 10% | 0 | 12.5% | NR | 24.3% | 3.7% | |
Massive haemorraghe | NR | 0 | 0 | 0 | NR | NR | 13% | |
Difficulty in feeding | NR | 0 | 0 | 0 | NR | NR | 20.4% |