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. 2013 Sep 10;8(9):e73918. doi: 10.1371/journal.pone.0073918

Table 7. Data of IMRT for locally recurrent NPC.

Lu et al [6] Chua et al [8] Lee et al [10] Han et al [7] Qiu et al [9] Current study
CMT EBRT
Case 49 31 13 16 239 70 54
rT stage
rT1 8.1% 10% 69% 25% 6.7% 4.3% 5.6%
rT2 18.4% 16% 15% 6% 18% 35.7% 14.8%
rT3 22.4% 29% 15% 31% 29.7% 28.6% 16.7%
rT4 51% 45% 0 38% 45.6% 34.3% 63%
GTV 47.2ml 28.1ml NR 37.69ml NR 59.4ml
PTV NR 39.2ml NR NR NR 134ml
Dose 71.4Gy (68.7-75.4) 56.8 (50.2-64), 32.3% had SRS boost of 8.5-12.5Gy 45Gy of EBRT and 20Gy of brachy- therapy 59.4Gy (39.6-61) 69.94Gy (61.7-78.7) 70Gy (50-77.4) 68.5Gy (49.8-76.8)
Chem NR 68% of induction 93% of peri-radiation 79.3% of concurrent 49% 70% of concurrent 51.9%
LC 100%-9m 61% -1 y 53%- 5y 52%- 5y 85.8% -5y 49.3% -3y 66.1%-2y
OS NR 63% -1 y 60%- 5y 57% -5y 44.9% -5y 51.9% -3y 44.3% -2y
Late toxicity 25% 8% 75% 70.3% 35.7% 48.1%
Brain necrosis NR 7% 8% 18.8% 25.8% NR 18.5%
Soft tissue necrosis NR 0 0 0 40.6% 15.7% 31.5%
Cranial neuropathy NR 10% 0 12.5% NR 24.3%  3.7%
Massive haemorraghe NR 0 0 0 NR NR 13%
Difficulty in feeding NR 0 0 0 NR NR 20.4%