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. Author manuscript; available in PMC: 2014 Aug 1.
Published in final edited form as: Arterioscler Thromb Vasc Biol. 2013 May 30;33(8):1892–1901. doi: 10.1161/ATVBAHA.113.301514

Figure 5. Enhanced electrical conduction during SKCa/IKCa blockade is greater along endothelium of Old vs. Young mice.

Figure 5

A, Representative recording of membrane potential responses at 500 μm (Vm2) from current injected at site 1 (±0.1 to 3 nA) in endothelial tube of Young. Note slight depolarization and enhanced Vm2 responses during apamin (Ap, 300 nmol/L) + charybdotoxin (ChTx, 100 nmol/L). B, As in A for Old. Note more negative resting Vm with reduced Vm2 responses vs. Young. During Ap + ChTx, note greater depolarization and enhancement of Vm2 responses vs. Young. C, Summary data (means ± S.E.) for conduction amplitude (CA) at rest (Control) and during Ap alone (n=5), ChTx alone (n=5) and in combination (n=11) within respective age groups. D, Data from C expressed as Fraction of Control CA within respective age groups. In C and D, note greater effect of ChTx vs, Ap on restoring CA in Old. *P<0.05 vs. Old for respective condition; +P<0.05 vs. respective Young Control; #P<0.05 vs. respective Old Control.