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. Author manuscript; available in PMC: 2014 Sep 1.
Published in final edited form as: Mol Genet Genomics. 2013 Jun 21;288(9):401–412. doi: 10.1007/s00438-013-0759-3

Figure 4.

Figure 4

RRM1 mutations and sequence alignments. A. The four PAB proteins whose alignments are represented are described in Figure 1. The RRM1 domains are gray color residues between the black color residues as shown. The RRM1 domains of first three proteins are from 12 to 86. RRM1 within PAB1 protein is from 40 to 113. The consensus symbol “*” means that the residues are identical in all sequences in the alignment, “:” means that conserved substitutions have been observed and “.” means that semi-conserved substitutions are observed. B. RRM1 sequence alignment of PABPC1 protein with PAB1 protein. RRM1 contains four β-sheets, showing as β1-β4 (Deo et al 1999). The amino acid residues numbers of PAB1 are showed above the sequences. The mutations used for deadenylation assays are identified by vertical linesand the grouped mutations that were created are linked together as shown.