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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Hear Res. 2013 Jun 18;304:41–48. doi: 10.1016/j.heares.2013.06.003

Fig. 4.

Fig. 4

The dfwi5 allele strongly interacts with the ahl locus. Variability of ABR thresholds in early generations of +/dfwi5 mice segregates with the presence of the Cdh23753A allele at the ahl locus. Mice negative for the Cdh23753A allele had the best sensitivity of +/dfwi5 animals (open squares, n=14), while +/dfwi5 mice also heterozygous for the Cdh23753A allele have increased thresholds (half-filled squares, n=11) and one +/dfwi5 mouse homozygous for the Cdh23753A allele had severely elevated thresholds (filled squares, n=1). Average thresholds of wild-type littermates (black inverted triangles) are shown for reference. ^ Indicates no threshold was detectable at this frequency; statistics were calculated for this point as if the threshold was the highest presented intensity. Error bars represent SEM. *p<0.05 and ***p<0.001 in a Bonferroni post-hoc test following a two-way ANOVA relative to +/dfwi5 animals with one less copy of the Cdh23753A allele.