Table1. MetS Cohort phenotypic characteristics and heritability levels.
Table 1 shows mean (±SD) and additive heritability of 42 clinical and biologic phenotypes of MetS. For cohort recruitment and phenotyping, see Methods. Clinical phenotypes were measured in 1,137 individuals from 85 extended families that contributed highly to the linkages at 3q27 and 17p12 loci. Biologic phenotypes were measured in 503 individuals.
| Trait | Mean | Heritability ± SE | |
|---|---|---|---|
| Body composition and insulin responsiveness | Weight, kg | 87.57 ± 27.36 | 0.47 ± 0.06 |
| Height, cm | 167.7 ± 12.45 | 0.56 ± 0.05 | |
| BMI, kg/m2 | 30.94 ± 9.31 | 0.44 ± 0.06 | |
| Waist circumference (WC), cm | 95.56 ± 21 | 0.40 ± 0.06 | |
| Hip circumference (HC), cm | 107.94 ± 22.04 | 0.57 ± 0.05 | |
| Waist to Hip ratio (WHR) | 0.89 ± 0.1 | 0.31 ± 0.06 | |
| Total Fat Mass (Fatkg), kg | 32.36 ± 16.47 | 0.50 ± 0.1 | |
| Total Fat Mass (Fatpct),% | 36.61 ± 12.14 | 0.48 ± 0.1 | |
| Total Lean Mass (Leankg), kg | 51.87 ± 13.56 | 0.66 ± 0.09 | |
| Total Lean Mass (Leanpct), % | 65.58 ± 31.75 | 0.44 ± 0.1 | |
| Subcutaneous Fat (SubQF), g | 311.9 ± 176.7 | 0.57 ± 0.1 | |
| Visceral Fat (VF), g | 177.9 ± 111.3 | 0.32 ± 0.07 | |
| Total Abdominal Fat (TAF), g | 489.8 ± 248.8 | 0.51 ± 0.1 | |
| Respiratory Quotient (RQ) | 0.83 ± 0.08 | 0.35 ± 0.09 | |
| Resting Energy Expenditure (REE), kcal/24 hrs | 1740.5 ± 342.21 | 0.31 ± 0.09 | |
| REE/weight, kcal/24hrs/kg | 19.26 ± 3.47 | 0.32 ± 0.11 | |
| REE/Lean mass (REE/LM), kcal/24hrs/kg | 33.48 ± 6.18 | 0.36 ± 0.1 | |
| Fasting Glucose (FG), mmol/l | 4.86 ± 1.64 | 0.38 ± 0.05 | |
| Fasting Insulin (FI),pmol/l | 107.5 ± 105.6 | 0.30 ± 0.05 | |
| Insulin/glucose (IGR) | 0.25 ± 0.62 | 0.25 ± 0.05 | |
| Homeostasis model assessment (HOMA) | 4.31 ± 8.5 | 0.30 ± 0.05 | |
| Insulin Sensitivity (SI), (× 10−4/min/μU/ml) | 3.05 ± 2.83 | 0.15 ± 0.09 | |
| Glucose Effectiveness (SG), min−1 | 0.02 ± 0.01 | 0.13 ± 0.08 | |
| Acute Insulin Response to glucose (AIRG), μU/ml × 10min | 467.02 ± 400.51 | 0.52 ± 0.08 | |
| Disposition Index (DI), AUC (Insulin0-10 min) × SI | 1191.18 ± 1081.76 | 0.26 ± 0.09 | |
|
| |||
|
Lipids/lipoprotein profiles
and cardiovascular performanc |
Triglycerides (TG), mmol/l | 1.33 ± 1.29 | 0.38 ± 0.06 |
| Total Cholesterol (TC), mmol/l | 4.88 ± 1.16 | 0.34 ± 0.05 | |
| LDL-cholesterol (LDL-c), mmol/l | 3.19 ± 0.98 | 0.28 ± 0.05 | |
| Calculated LDL-C (cal. LDL-c), mmol/l | 3.25 ± 1.16 | 0.35 ± 0.05 | |
| HDL-cholesterol (HDL-c), mmol/l | 1.06 ± 0.37 | 0.64 ± 0.06 | |
| HMED, nm | 8.93 ± 0.55 | 0.53 ± 0.07 | |
| LMEDn, nm | 27.03 ± 0.78 | 0.59 ± 0.07 | |
| LDLppd, nm | 27.35 ± 1.2 | 0.65 ± 0.07 | |
| BMED, nm | 27.55 ± 1.17 | 0.63 ± 0.07 | |
| Systolic Blood Pressure (sBP), mmHg | 124.58 ± 18.57 | 0.24 ± 0.05 | |
| Diastolic Blood Pressure (dBP), mmHg | 77.13 ± 11.27 | 0.24 ± 0.06 | |
| Pulse, beats/min | 71.17 ± 14.14 | 0.20 ± 0.05 | |
|
| |||
|
Adipokine
and cytokines |
Adiponectin, ng/ml | 9.51 ± 5.6 | 0.48 ± 0.06 |
| Leptin, ng/ml | 19.28 ± 17.3 | 0.24 ± 0.06 | |
| TNF-alpha, pg/ml | 4.44 ± 6.28 | 0.32 ± 0.06 | |
| Interleukin-1 beta (IL-1β), pg/ml | 1.33 ± 18.42 | 0.16 ± 0.06 | |
| Interleukin-6 (IL-6), pg/ml | 7.68 ± 53.48 | 0.25 ± 0.07 | |