Table 4. Association of lymphocyte expression levels of prioritized genes with MetS phenotypes at 3q27 QTL.

For gene prioritization strategy, see text. SNP associations with phenotypes are depicted in Table 2. The values shown represent the level of significance (p-value) of association between prioritized gene transcript levels and MetS phenotypes.

	Phenotype	ATP11B	FGF12	IGF2BP2	LPP	MCF2L2	NLGN1	TBL1XR1
Body composition and insulin responsiveness	weight	0.51	0.35	0.00	0.62	0.96	0.18	1.00
	height	0.17	0.14	0.12	0.97	1.00	0.31	0.00
	BMI	1.00	0.89	0.00	0.74	0.36	0.21	0.34
	WC	0.44	0.63	0.00	0.69	0.73	0.68	0.34
	HC	0.01	0.57	0.01	0.50	0.63	0.80	0.28
	WHR	0.02	0.39	0.12	0.37	0.51	0.92	0.69
	Fatkg	0.61	0.73	0.02	0.34	0.84	0.16	0.09
	Fatpct	0.93	0.96	0.27	0.48	0.18	0.18	0.65
	Leankg	0.14	0.70	0.00	0.86	0.33	0.10	0.01
	Leanpct	0.93	1.00	0.26	0.43	0.25	0.16	0.55
	SubQF	0.82	0.28	0.06	0.74	0.84	NA	0.96
	VF	0.81	0.28	0.21	0.91	0.83	NA	0.89
	TAF	0.86	0.24	0.11	0.80	0.94	NA	0.86
	RQ	0.18	0.90	0.01	0.22	0.06	NA	0.84
	REE	0.81	0.63	0.00	0.20	0.45	NA	0.52
	REE/weight	0.24	0.99	0.09	0.03	0.12	NA	0.29
	REE/leanmass	0.43	0.86	0.38	0.08	0.93	NA	0.31
	FG	0.57	0.77	0.21	0.71	0.74	0.04	0.83
	FI	0.73	0.12	0.68	0.05	0.81	0.85	0.13
	IGR	0.55	0.20	0.68	0.05	0.99	0.58	0.13
	HOMA	0.79	0.15	0.40	0.06	0.67	0.41	0.16
	SI	0.07	0.13	0.04	0.67	0.04	NA	0.64
	SG	0.83	0.51	0.17	0.75	0.37	NA	0.62
	AIR	0.19	0.15	0.45	0.94	0.98	NA	0.31
	DI	0.18	0.26	0.02	0.49	0.83	0.57	0.73
Lipids/lipoprotein profiles and cardiovascular performance	TG	0.46	0.35	0.90	0.01	0.30	0.44	0.62
	TC	0.64	0.91	0.12	0.94	0.77	0.45	0.84
	LDL-c	0.45	0.68	0.02	0.60	0.35	0.86	0.17
	cal. LDL-c	0.50	0.58	0.76	0.67	0.62	0.75	0.95
	HDL-c	0.20	0.35	0.08	0.02	0.64	0.15	0.67
	HMED	0.81	0.97	0.02	0.49	0.60	0.08	0.56
	LMEDn	0.81	0.93	0.10	0.67	0.44	0.46	0.76
	LDLppd	0.56	0.58	0.03	0.89	0.01	0.31	0.35
	BMED	0.88	0.50	0.19	0.90	0.04	0.86	0.65
	sBP	0.40	0.51	0.07	0.79	0.45	0.45	0.83
	dBP	0.79	0.25	0.71	0.62	0.37	0.49	0.67
	Pulse	0.67	0.70	0.56	0.36	0.23	0.30	0.00
Adipokine and cytokines	Adiponectin	0.22	0.30	0.05	0.37	0.92	0.57	0.84
	Lepin	0.76	0.61	0.05	0.73	0.10	0.77	0.40
	TNF-alpha	0.90	0.81	0.94	0.32	0.95	0.45	0.63
	IL-1β	0.58	0.59	0.59	0.04	1.00	0.57	0.81
	IL-6	0.34	0.87	0.57	0.82	0.42	0.84	0.79