Table 5. Association of lymphocyte expression levels of prioritized genes with MetS phenotypes at 17p12 QTL.

For gene prioritization strategy, see text. SNP associations with phenotypes are depicted in Table 3. The values shown represent the level of significance (p-value) of association between prioritized gene transcript levels and MetS phenotypes.

	Phenotype	COPS3	COX10	PMP22	RICH2	TNFRSF13B	TRPV2	HS3ST3B1
Body composition and insulin responsiveness	weight	0.30	0.04	0.58	0.26	0.43	0.92	0.58
	height	0.85	0.18	0.73	0.57	0.86	0.67	0.21
	BMI	0.19	0.01	0.71	0.41	0.24	0.95	0.26
	WC	0.67	0.23	0.46	0.45	0.64	0.94	0.76
	HC	0.59	0.09	0.14	0.35	0.24	1.00	0.41
	WHR	0.66	0.13	0.54	0.95	0.03	0.37	0.26
	Fatkg	0.99	0.22	0.41	0.14	0.65	0.03	0.46
	Fatpct	0.93	0.16	0.62	0.19	0.36	0.03	0.19
	Leankg	1.00	0.23	0.61	0.03	0.58	0.81	0.49
	Leanpct	0.89	0.17	0.53	0.17	0.46	0.03	0.19
	SubQF	0.55	0.23	0.67	0.39	0.23	0.04	NA
	VF	0.88	0.40	0.59	0.44	0.58	0.80	NA
	TAF	0.75	0.24	0.65	0.49	0.24	0.10	NA
	RQ	0.83	0.20	0.84	0.16	0.01	0.39	NA
	REE	0.45	0.94	0.59	0.02	0.94	0.75	NA
	REE/weight	0.85	0.97	0.99	0.00	0.83	0.99	NA
	REE/leanmass	0.07	1.00	0.93	0.16	0.94	0.00	NA
	FG	0.33	0.17	1.00	0.64	0.11	0.39	0.66
	FI	0.68	0.07	0.07	0.64	0.14	0.53	0.81
	IGR	0.26	0.20	0.15	0.34	0.20	0.58	0.95
	HOMA	0.90	0.06	0.15	0.81	0.23	0.48	0.73
	SI	0.41	0.81	0.84	0.05	0.12	0.16	NA
	SG	0.10	0.05	0.88	0.62	0.13	0.49	NA
	AIR	0.28	0.38	0.65	0.03	0.60	0.42	NA
	DI	1.00	0.59	0.54	0.07	0.34	0.35	0.34
Lipids/lipoprotein profiles and cardiovascular performance	TG	0.70	0.04	0.01	0.79	0.91	0.19	0.47
	TC	0.91	0.63	0.68	0.69	0.21	0.40	0.90
	LDL-c	0.83	0.28	0.32	0.27	0.75	0.45	0.99
	cal. LDL-c	0.99	0.91	0.26	0.45	0.26	0.40	0.84
	HDL-c	0.31	0.46	0.42	0.19	0.26	0.29	0.97
	HMED	0.26	0.22	0.04	0.78	0.03	0.19	0.21
	LMEDn	0.71	0.55	0.16	0.82	0.06	0.63	0.28
	LDLppd	0.74	0.81	0.03	0.08	0.00	0.15	0.90
	BMED	0.96	0.95	0.46	0.27	0.00	0.34	0.43
	sBP	0.96	0.47	0.54	0.41	0.20	0.30	0.89
	dBP	0.54	0.89	0.09	0.95	0.33	0.22	0.43
	pulse	0.50	0.94	0.36	0.81	0.34	0.07	0.33
Adipokine and cytokines	adiponectin	0.95	0.76	0.77	0.47	0.29	0.45	0.34
	leptin	0.55	0.69	0.45	0.05	0.08	0.99	0.14
	TNF-alpha	0.02	0.17	0.70	0.60	0.81	0.46	0.21
	IL-1β	0.39	0.53	0.21	0.48	0.40	0.53	0.40
	IL-6	0.66	0.76	0.31	0.05	0.55	0.34	0.36