Table 6. Summary illustrating the prioritized genes at 3q27 and 17p12 QTLs.

For prioritized genes see Table 2 and 3. For phenotype abbreviations, see Table 1. Identifier phenotype is the one that was highly associated with a SNP that mapped to that gene. Correlated phenotypes are those that were found to be genetically correlated significantly with the identifier phenotype.

Annotated associated genes	Original QTL region	Identifier phenotype	Correlated biological phenotypes	Biological function
LPPab	3q27	AIR	Fatkg, DI, leptin	signal transduction to celll adhesion sites; cell to cell communication
IGF2BP2ab	3q27	WHR	VF, TAF, REE, HMED, LMEDn, LDLppd, BMED,TNF-alpha	neonatal development, body fat regulation and lipid metabolism
TBL1XR1a	3q27	BMI, weight, Leanpct, TAF, REE,SG, TG	WHR, Fatkg, Fatpct, Leankg, Leanpct, SubQF, VF, REE/weight, REE/Leanmass, SI, AIR, DI, HMED, leptin, IL-6	member of WD40 protein family known to regulate signal transduction, RNA processing, vesicular trafficking, cytoskeletal assembly and cytotypic differentiation.
NLGN1a	3q27	Leankg	Fatkg, SubQF, VF, TAF, REE, REE/weight, REE/leanmass, SI, AIR, HMED	member of a family of neuronal cell surface proteins, known to act as splice site-specific ligands for beta-neurexins that could be involved in the formation and remodeling of central nervous system
ATP11Ba	3q27	LDLppd	WHR, Fatkg, HMED,BMED,TNF- alpha	member of the ATPase family that participate the uphill transport of ions across cell membranes, including H+,Na+, K+ and Ca++
MCF2L2a	3q27	Pulse	Leankg, SubQF, TAF, REE, SI, adiponectin, leptiin	member of the guanine exchange factor family. Together with ADIPQ, SOX2 polymorphism influence diabetic complications.
FGF12	3q27	IL-6	VF	Member of the fibroblast growth factor family possess broad mitogenic and cell survival activities,involved in several biological functions.
TNFRSF13B ab	17p12	VF, TAF, REE, sBP	weight, BMI, WC, HC, WHR,Fatkg,Fatpct,Leankg,Leanpc t,SubQF,REE/weight, FI, IGR,, HOMA, SI,SG,DI, HDL-c, dBP,pulse, leptin, IL-6	A lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily, which plays a crutial role in humoral immunity.
HS3ST3A1ab	17p12	HC, Fatkg, Leankg, FI, IGR, HOMA, SG, AIR, Adiponectin, TNF-alpha	weight, height,, BMI, WC, WHR,SubQF,VF, TAF,RQ, REE, REE/weight, REE/leanmass, FG, SI, DI,TG,TC, LDL-c, cal. LDL-c, HDL-c, HMED, LMEDn, LDLppd, BMED, sBP,pulse, leptin, IL-1β, IL- 6	A biosynthesis enzyme of heparan sulfate find structures, whose substrates are important in the cellular uptake and biological effects of the lipoproteins that carry out multiple biologic activities.
MYOCDa	17p12	Weight, BMI, WC, DI, TC, cal. LDL-c, dBP	height, hips,WHR, Fatkg, Fatpct, Leankg, Leanpct, SubQF, VF,TAF,REE, REE/weight, REE/leanmass, FI, IGR, HOMA, SI,SG, AIR,TG, LDL-c, HDL-c, HMED, sBP, pulse, leptin, IL-6	A nuclear protein, a transcriptional coactivator that modulates the function of cardiac and smooth-muschle cells. Important in cardiogenesis and smooth muscle cell differentiation.
RICH2a	17p12	Fatpct, TG	weight, BMI, WC,HC,WHR, Fatkg,Leanpct, SubQF, VF, TAF, REE, REE/weight,REE/leanmass,FI, IGR, HOMA, SI,AIR,TC,HDL-c, leptin	GTPase activator protein, which activate CDC42 and Rac-1, known to interfere with platelet growth factor BB-induced membrane ruffling.
TRPV2a	17p12	RQ	Pulse	A channel protein in response to environmental stresses.
COX10a	17p12	FG	FI, HOMA, AIR, leptin	The terminal component of the mitochodrial respiratory chain, which catalyzes the electron transfer from reduced cytochrome c to oxygen. Mutations were linked to cytochrome c function deficiency.
PMP22a	17p12	SI, HMED	weight, BMI, WC, HC, WHR, Fatkg, Fatpct,Leankg, Leanpct,SubQF, VF, TAF, REE/weight, FI, IGR, HOMA, TG, HDL-c, LMEDn, LDLppd, BMED,pulse	the major component of the myelin structure in the peripheral nervous system that might function in growth regulation, and in myelinization in the peripheral nervous system
MPRIPa	17p12	LMEDn, LDLppd, BMED	WHR,Fatkg, FI, IGR, HOMA, TG, HDL-c, HMED,TNF-alpha	Target myosin phosphatases interacting with RhoA and ROCK1 to regulate actin cytoskeleton.
COPS3	17p12	IL-6	BMI, VF	The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction and protects proteins from ubiquitin-dependent degradation.

^aCandidate genes prioritized from SNP association analysis whose transcript levels are associated with MetS phenotypes

^bBiologic candidate gens with the highest prioritization