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. Author manuscript; available in PMC: 2014 Sep 15.
Published in final edited form as: J Immunol. 2013 Aug 19;191(6):2948–2955. doi: 10.4049/jimmunol.1301173

FIGURE 3.

FIGURE 3

IL-21 production and IL-21 receptor signaling are not required for KRN T cell survival or TFH differentiation. (A) Transferred KRN T cells were identified in the spleen 8 and 29-31 days post-transfer by flow cytometry as CD45.1− CD4+. Percent and total number of transferred cells were shown. (B) TFH differentiation of transferred cells was determined by CXCR5 and intracellular Bcl6 expression. Percent and total number of TFH cells are shown. Day 8 results are from four experiments (n = 5 - 10 mice per group), Days 29-31 results are from two experiments (n = 6 - 8 mice per group). Mean and standard error are shown. Student’s t-test: ns, p ≥ 0.05; *, p < 0.05; **, p< 0.01; ***, p < 0.001.