Table 1.
Characteristics of 19 hereditary prostate cancer (PCa) families with whole-exome sequencing (WES) data
| Family ID | No. PCa cases | Mean age at PCa diagnosis | No. WES cases with aggressive PCaa | No. WES cases with early-onset PCaa | No. WES cases per family | No. WES unaffected men per family |
|---|---|---|---|---|---|---|
| 1 | 9 | 64.4 | 2 | 3 | 4 | 1 |
| 2 | 7 | 62.2 | 2 | 3 | 4 | |
| 3 | 7 | 69.9 | 2 | 2 | 5 | 1 |
| 4 | 9 | 67.3 | 4 | 2 | 5 | 1 |
| 5 | 8 | 68.0 | 3 | 1 | 4 | 1 |
| 6 | 6 | 60.6 | 1 | 5 | 5 | |
| 7 | 11 | 64.6 | 2 | 2 | 3 | 1 |
| 8 | 5 | 54.0 | 2 | 3 | 3b | 1 |
| 9 | 7 | 57.2 | 3 | 2 | 3 | |
| 10 | 6 | 66.0 | 3 | 2 | 4 | |
| 11 | 7 | 59.0 | 5 | 3 | 5b | |
| 12 | 9 | 68.4 | 2 | 1 | 4 | 1 |
| 13 | 9 | 60.0 | 1 | 5 | 5 | |
| 14 | 10 | 65.1 | 2 | 6 | 6 | 1 |
| 15 | 7 | 61.9 | 3 | 3 | 4 | |
| 16 | 8 | 63.4 | 0 | 4 | 4 | |
| 17 | 9 | 66.2 | 1 | 2 | 2 | 1 |
| 18 | 10 | 65.6 | 2 | 3 | 5 | 1 |
| 19 | 7 | 67.8 | 3 | 3 | 5 | 1 |
| Total | 151 | 63.8 | 43 | 55 | 80 | 11 |
a
A total of 23 cases had both aggressive and early-onset PCa.
b
WES failed or was of low quality for one of the affected men in these families.