Table 2. Summary of changes in Na+ and Cl- ICM currents (µA/cm2).
| CF | Non-CF | Difference | |
|---|---|---|---|
| Condition | n = 17 | n = 44 | (CF vs non-CF) |
| Change Amiloride (µA/cm2) | |||
| Mean (SD) | -10.5 (29.08) | -21.4 (27.79) | Mean diff = -11.0 |
| Median | -1.1 | -12.3 | 95% CI = (6.4, -28.4) |
| Min, Max | -112.5, 7.9 | -159, 6 | P = 0.002* |
| Change cAMP (forskolin/IBMX)** (µA/cm2) | |||
| Mean (SD) | -5.0 (12.67) | 99.5 (71.84) | Mean diff = 102.6 |
| Median | -0.9 | 92 | 95% CI = (128.0, 81.1) |
| Min, Max | -35.7, 16.4 | 6.1, 269.4 | P < 0.001* |
| Change CCh (µA/cm2) | |||
| Mean (SD) | 5.9 (10.21) | 102.2 (69.21) | Mean diff = 96.3 |
| Median | 3.9 | 97.26 | 95% CI = (118.7, 73.9) |
| Min, Max | -12.7, 28.1 | 0.8, 318.7 | P < 0.001* |
| Change cAMP + CCh (µA/cm2) | |||
| Mean (SD) | 0.8 (14.66) | 201.7 (131.98) | Mean diff = 200.9 |
| Median | -1.8 | 193.1 | 95% CI = (243.1, 158.6) |
| Min, Max | -30.3, 31.9 | 19.5, 588.1 | P < 0.001* |
| Change Bumetanide (µA/cm2) | |||
| Mean (SD) | 8.8 (9.7) | -35.8 (31.35) | Mean diff = -44.6 |
| Median | 6.4 | -27.4 | 95% CI = (-33.7, -55.6) |
| Min, Max | -2.6, 30.9 | -166.2, 3.3 | P < 0.001* |
cAMP, forskolin/ IBMX; CCh, carbochol; CI, confidence interval
*
P values were obtained using the Mann-Whitney test
**
Represents the primary clinical endpoint: difference in mean change in current for cAMP-stimulated tissue between CF and non-CF participants.
ICM data from 16 CF and 41 non-CF subjects were available for analysis.