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. 1970 Sep;20(3):469–473. doi: 10.1128/am.20.3.469-473.1970

Environmental and Nutritional Factors Affecting the Production of Rubratoxin B by Penicillium rubrum Stoll 1

A Wallace Hayes 1, Elwanda P Wyatt 1, Patricia A King 1
PMCID: PMC376961  PMID: 5485727

Abstract

Rubratoxin B can be produced in a semisynthetic medium by Penicillium rubrum under varying environmental and nutritional conditions. Maximum production (552.0 mg/500 ml) was obtained with P. rubrum NRRL A-11785 grown in stationary cultures of Mosseray's simplified Raulin solution supplemented with 2.5% malt extract broth at ambient temperature. Zinc is required at levels of at least 0.4 mg per liter. In the absence of iron sulfate, there was a 50-fold reduction in rubratoxin B production but not in growth. No toxin was produced by this isolate in 5- or 7-liter fermentors.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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