Table 5.

Incidence of grade 3 and 4 neutropenia for different covariates, obtained using stochastic simulations (n = 2000) using the registered eribulin dose of 1.4 mg m⁻²

Parameter	Covariate	Neutropenia incidence (%)		Change in neutropenia incidence* (%)
		Grade 3	Grade 4	Grade 3	Grade 4
Base model		26.6	16.85	0	0
ANC0	Albumin 50% reduced	25.05	40.15	−1.55	23.3
	Received blood transfusion	19.95	11.20	−6.65	−5.65
	Received prior platinum-containing chemotherapy	25	14.70	−1.60	−2.15
	Sex (male)	21.6	12.05	−5.00	−4.80
MTT	Albumin 50% reduced	23.15	55.95	−3.45	39.10
	Alkaline phosphatase 50% reduced	25.65	13.55	−0.95	−3.30
	Bilirubin 50% reduced	25.45	13.15	−1.15	−3.70
	Received G-CSF	27.05	15.1	0.45	−1.75
	Lactate dehydrogenase 50% reduced	27.3	16.50	0.70	−0.35
SLOPE	Albumin 50% reduced	29.6	35.80	3.00	18.95
	Aspartate transaminase 50% reduced	24.65	12.45	−1.95	−4.4
	Received G-CSF	28.95	20.35	2.35	3.50

^*Compared with the base model incidences. Abbreviations are as follows: G-CSF, granulocyte colony-stimulating factor; SLOPE, linear drug effect coefficient.