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Formation rates of (A) D3OG and (B) D2OG after incubation of dapagliflozin with human kidney, liver or intestine microsomes at a protein concentration of 0.25 mg ml−1 in the presence of uridine 5′-diphosphoglucuronic acid. D2OG, dapagliflozin 2-O-glucuronide; D3OG, dapagliflozin 3-O-glucuronide; T2DM, type 2 diabetes mellitus. 
, human liver microsomes; 
, human kidney microsomes; 
, human intestine microsomes
