Table 2.
Summary of docetaxel pharmacokinetic parameters
| Parameter | Day 1: docetaxel alone | Day 22: with pretreatment of E. purpurea | P value |
|---|---|---|---|
| AUC0–∞ (ng ml−1 h) | 3278 ± 1086 | 3480 ± 1285 | 0.51 |
| Cmax (ng ml−1) | 2224 ± 609 | 2097 ± 925 | 0.30 |
| t1/2 (h) | 30.8 ± 19.7 | 25.6 ± 5.9 | 0.56 |
Pharmacokinetic data are given as means ± SD and were obtained on day 1 (docetaxel alone) and day 22 (14 days after start of Echinacea purpurea). The P values were obtained from Student's paired t test. Abbreviations are as follows: AUC0–∞, area under the docetaxel plasma concentration–time curve extrapolated to infinity; Cmax, peak plasma concentration; and t1/2, half-life of the terminal disposition phase.