Table 1.
Characteristics of Thai women during the second and third trimesters of pregnancy, at delivery and at 6–12 weeks post-partum, as well as infant characteristics at delivery
| Median (range) or # of subjects (%) | |
|---|---|
| Second trimester (n = 13) | |
| Age (years) | 32.5 (18.8–35.7) |
| Weight (kg) | 59.0 (48.0–84.0) |
| Gestational age (weeks) | 25.1 (21.0–27.0) |
| CD4 + cell count (cells μl−1) | 352 (110–581) |
| HIV-1 RNA (copies ml−1) | 144 (<40–68 920) |
| Duration of indinavir/r use (weeks) | 4.9 (2.4–8.0) |
| Third trimester (n = 25)* | |
| Age (years) | 29.8 (18.9–40.8) |
| Weight (kg) | 60.5 (50.0–85.0) |
| Gestational age (weeks) | 31.1 (29.3–37.0) |
| Duration of indinavir/r use (weeks) | 9.0 (2.1–18.0) |
| CD4 + cell count (cells μl−1) | 393 (129–758) |
| HIV-1 RNA (copies ml−1) | <40 (<40–903) |
| HIV1 RNA ≤ 40 cps ml−1 | 14/25 (56%) |
| Other ARVs: ZDV/ d4T/3TC/TDF | 21/4/26/1 |
| Delivery (n = 26) | |
| Weight (kg) | 62.5 (50.0–87.0) |
| Gestational age (weeks) | 38.4 (35.3–41.9) |
| HIV-1 RNA (copies ml−1) | <40 (<40–1309) |
| HIV-1 RNA ≤ 400 cps ml−1 | 25/26 (96%) |
| HIV-1 RNA ≤ 40 cps ml−1 | 21/26 (81%) |
| Post-partum (n = 26) | |
| Weight (kg) | 55.0 (44.0–81.0) |
| Timing of PK sampling (weeks) | 8.6 (2.6–10.3) |
| Infants (n = 26) | |
| Infant weight at birth (g) | 2 830 (2 200–3 548) |
*
Includes those women enrolled during the second trimester.